Annie vs Cassiopeia MID Matchup Guide | LaneStomp

Back to matchup selector

Champion

Opponent

RoleGenerate matchup

Annie

VS

Mid

Cassiopeia

Annie vs Cassiopeia

Confidence mediumUpdated Jun 10, 2026

Overview

Use (R) to find picks and burst Cassiopeia quickly before she applies poison for extended trades.
Pressure Cassiopeia early to deny her calm scaling and avoid letting her set up sustained fights.
Manage mana carefully to avoid pushing wave unnecessarily and exposing yourself to Cassiopeia's poke.

Trading pattern

Burst with (Q) + (W) and 4th passive stack when (W) is down to reduce her escape options.
Punish missed (Q) poisons by trading aggressively before she can extend fights with (E).
Avoid extended trades where Cassiopeia can repeatedly cast (E) and sustain through damage.

Danger windows

Respect (R) stun, especially when facing her during all-in attempts.
Be cautious when her (W) is up as it grounds dashes and blocks your escape paths.
Avoid extended fights where Cassiopeia can stack poison and repeatedly cast (E) for sustained damage.

Early game

Play around level 6 to threaten all-ins with (R) and your burst combo.
Use (E) shield to mitigate poke damage and survive Cassiopeia's mid-range harassment.
Avoid pushing hard early to conserve mana and reduce chances of Cassiopeia punishing with sustained damage.

Power spikes

Level 6 unlocks (R), enabling strong pick potential and burst dominance in lane.
First completed AP item significantly increases burst damage and trade threat.
Respect Cassiopeia's level 6 (R) stun window to avoid getting locked down during engages.

Win conditions

Look for pick opportunities using (R) to initiate burst combos before Cassiopeia can apply poison.
Deny Cassiopeia safe scaling by pressuring her early and punishing missed (Q) poisons.
Use mid-game roams with (R) to snowball and leverage your burst and crowd control advantage.