Annie vs Vex MID Matchup Guide

Champion

Opponent

Start here

Read Overview → Trading Pattern → Danger Windows first for the fastest Mid lane plan.

Annie into Vexmedium

Overview

Use your burst combo with to find picks and punish Vex's immobility outside her ultimate.
Apply medium lane pressure to deny Vex's passive fear windows and limit her trade control.
Track Vex's ultimate cooldown to time all-ins and roams effectively.

Avoid trading when Vex's passive fear is active, as it punishes your engage attempts.
Respect Vex's window; she can reset fights and punish overextensions.
Be cautious pushing with on low mana, as it exposes you to Vex's all-in potential.

Farm with to conserve mana and avoid pushing with early.
Avoid extended trades before level 6 since Vex's passive fear gives her early pressure.
Look for level 6 all-ins when Vex's is down and she can't reset fights.

Level 6 with is a major spike; use it to secure picks and force Vex off the wave.
First completed AP item boosts your burst and wave control; pressure more confidently after.
Track Vex's level 6 and first AP item to avoid unfavorable all-ins during her spikes.

Land to stun and burst Vex with and before she reacts.
Punish Vex's immobility outside her cooldown by forcing all-ins and denying her passive fear.
Control trades and wave state to limit Vex's passive fear uptime and reduce her lane pressure.

Tactical tip

For Annie vs Vex, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 27, 2026