Camille should manage the lane by using terrain angles to threaten (E) engages and leverage her high mobility to avoid Sett's melee brawls.
Focus on denying Sett the ability to force extended trades by using short second-(Q) trades and disengaging before Sett can build grit stacks.
Trading pattern
Trade by preparing the second (Q) and only engage with (E) when you have a safe terrain angle to stun and follow up.
Avoid extended fights where Sett can build grit and use (W) shield and true damage effectively.
After using (E) and landing second (Q), disengage before Sett can retaliate or force a longer trade.
Danger windows
Be cautious when Sett has built grit and his (W) shield is up, as his trades become much stronger and can punish extended fights.
Avoid being near minions or terrain that enables (E) pull and stun, which can set up his (W) true damage.
After missing (E), Camille's engage and escape options are limited; play more defensively until (E) is off cooldown.
Early game
Use early waves to position near terrain for (E) angles and avoid prolonged fights before your first item spike.
Prioritize short trades that land the second (Q) true damage and disengage quickly to prevent Sett from stacking grit.
Avoid standing near minions to reduce Sett's chance to land (E) pulls and (W) center damage.
Power spikes
At first sheen-style item, Camille's second (Q) true damage becomes a reliable trade tool; use this to take sharper short trades and threaten side-lane picks.
At level 6, use (R) to lock down Sett after baiting his disengage or key abilities, preventing his escape and enabling kills.
Respect Sett's level 6 (R) slam as it can reposition you into unfavorable fights; maintain spacing to avoid forced brawls.
Win conditions
Use terrain to create safe (E) engage angles and punish Sett's positioning with short trades around second (Q).
Scale into side-lane pressure after first item spikes, using (R) to lock down isolated targets and secure picks.
Deny Sett extended melee trades to prevent him from building grit and gaining his trade advantage, forcing him into unfavorable fights.
Tip: For Camille vs Sett, read overview, trading pattern, and danger windows first for a fast Top lane check.