Camille vs Vayne TOP Matchup Guide | LaneStomp

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Camille

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Vayne

Camille vs Vayne

Updated Jun 2, 2026

Overview

Camille aims to control the lane with short trades around her second (Q) true damage and use terrain for safe (E) engages.
Focus on medium lane pressure to deny Vayne easy scaling and avoid giving her space to kite freely.
This is a scaling-focused matchup where Camille must leverage her item spikes and lockdown (R) to isolate and pick Vayne in side lanes.

Trading pattern

Prepare to land your second (Q) for true damage, then disengage before Vayne can retaliate or use (E).
Only commit (E) when you have a confirmed angle and (E) is on cooldown to avoid being stunned into terrain.
Use (W) slow to help land your (Q) trades and heal off poke, but avoid extended fights that favor Vayne's kiting and true damage.

Danger windows

Be cautious when your (E) is on cooldown, as your engage and escape options are limited, making you vulnerable to (E).
Avoid extended trades before your first item spike, as Vayne's ranged poke and true damage can punish you.
Watch for (R) stealth windows combined with (Q) repositioning, which can dodge your (R) and turn fights against you.

Early game

Use passive shield and short trades with second (Q) to chip Vayne without overextending early.
Avoid long trades before your first item spike and only use (E) when you have a clear terrain angle to stun.
Keep the wave near terrain to maximize your (E) threat and limit Vayne's ability to safely poke or kite.

Power spikes

At first sheen-style item, your second (Q) damage becomes reliable; use this to take sharper short trades and pressure side lanes.
At level 6, your (R) lockdown can guarantee picks by preventing Vayne's escape, so engage after baiting her defensive tools.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun; avoid extended fights where she can outplay your engage.

Win conditions

Use terrain to secure safe (E) engages and land your second (Q) true damage trades to chip Vayne down.
Reach your first item spike to increase trade payoff, then pressure side lanes and force isolated picks with (R).
Deny Vayne space to kite by controlling wave position and using your lockdown to prevent her escape, securing kills and splitpush advantage.