Cassiopeia vs Lissandra MID Matchup Guide | LaneStomp

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Champion

Opponent

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Cassiopeia

VS

Mid

Lissandra

Cassiopeia vs Lissandra

Confidence mediumUpdated Jun 10, 2026

Overview

Control mid-range space to force extended trades and repeatedly cast (E) on poisoned targets.
Deny Lissandra safe (E) engages by holding (W) to ground her mobility and punish commits.
Maintain medium lane pressure to prevent her from setting up roams or flanks with (E).

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison and block her (E) engage or escape.
Follow up with repeated (E) casts to maximize damage while she remains poisoned.
Hold (R) to punish her if she faces you during all-ins or tries to commit into your zone.

Danger windows

Be cautious when (R) is available; it can stun or self-peel against your aggression.
Avoid extended trades when (W) is down, as she can engage or escape more freely with (E).
Punish Lissandra if she uses (E) forward without a safe recast or follow-up opportunity.

Early game

Use (Q) to apply poison early and prepare for sustained (E) damage before she can engage.
Respect (W) root range to avoid getting locked down in early trades.
Keep wave state neutral or slow push to limit her (E) flank angles and jungle follow-up.

Power spikes

Level 6 (R) greatly increases kill threat; use it to force picks or defensive resets.
First mana/AP item boosts sustained trades; pressure waves more confidently post-item.
Respect Lissandra's level 6 (R) lockdown and self-peel, which makes direct all-ins riskier.

Win conditions

Win extended fights by landing poison and out-DPSing her with repeated (E) casts.
Use (W) to deny her mobility and escape paths, forcing bad trades or zoning her.
Capitalize on (R) windows to stun or slow her when she faces you, securing kills or lane dominance.