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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Cassiopeia vs Neeko MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Cassiopeia

VS

Mid

Neeko

Cassiopeia vs Neeko

Confidence mediumUpdated Jun 10, 2026

Overview

Control mid-range space by landing (Q) to apply poison and force extended fights.
Pressure Neeko to deny minion-enhanced (E) angles and disguise setups.
Use (W) to ground dashes and maintain spacing against Neeko's mobility.

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison, then spam (E) for damage.
Use (W) to punish Neeko's dashes or force her to reposition.
Avoid extended trades if (Q) misses or (W) is down to prevent Neeko's burst and root.

Danger windows

Neeko is dangerous when (E) roots through minions and (R) is available for burst knock-up.
If (W) is down, Neeko can dash or escape more freely, increasing her threat.
Missing (Q) reduces your trade threat, making you vulnerable to Neeko's burst and root.

Early game

Use (Q) early to apply poison and keep trade threat high by avoiding misses.
Hold (W) to block Neeko's mobility or escape attempts before she commits.
Track Neeko's disguise and clone to avoid getting caught off-guard in trades.

Power spikes

Level 6 (R) punishes Neeko when she commits facing you; use for all-ins or picks.
First mana/AP item boosts sustained (E) damage; pressure waves and trades more confidently.
Respect Neeko's level 6 (R) for burst and crowd control threat to avoid risky trades.

Win conditions

Win extended fights by maintaining poison and repeatedly casting (E) while using (W) and (R) to punish movement.
Deny Neeko safe minion positioning to reduce her (E) angles and disguise effectiveness.
Use (R) to stun or slow Neeko when she commits facing you to turn all-ins in your favor.

Tip: For Cassiopeia vs Neeko, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup