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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Cassiopeia vs Ryze MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Cassiopeia

VS

Mid

Ryze

Cassiopeia vs Ryze

Confidence mediumUpdated Jun 10, 2026

Overview

Control mid-range spacing to land poison and force extended trades against Ryze's short range.
Pressure Ryze early to deny safe scaling farm and disrupt his (E) and (Q) rotations.
Use (W) to punish Ryze's mobility and force fights on your terms.

Trading pattern

Initiate trades by landing (Q) or (W) to poison, then spam (E) to out-damage Ryze's burst.
Respect (W) root cooldown; trade aggressively when it is down.
Avoid trading if (Q) misses or (W) is down, as Ryze can retaliate with spell rotations.

Danger windows

Ryze is dangerous when he has mana and cooldowns to cycle (E) and (Q) with (W) root ready.
Avoid extended trades while (W) root is available to prevent being locked down.
Punish Ryze's low mana or (W) cooldown by forcing fights or zoning him from farm.

Early game

Use (Q) and (W) to apply poison before Ryze steps forward to cast (E) and (W).
Avoid trades when (W) root is ready to prevent getting locked down.
Maintain mana to extend trades with repeated (E) on poisoned targets after Ryze commits.

Power spikes

Level 6 (R) lets you punish Ryze if he faces you during all-ins.
First mana/AP item increases sustained damage and mana for longer trades.
Respect Ryze's first mana/AP item and level 6 (R) for his damage and map pressure.

Win conditions

Land poison and use (W) to trap Ryze, enabling repeated (E) damage.
Use (R) to punish Ryze when he commits and faces you during all-ins.
Deny Ryze safe farm and force extended trades to prevent his scaling and map plays.

Tip: For Cassiopeia vs Ryze, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup