Cassiopeia vs Yone MID Matchup Guide | LaneStomp

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Champion

Opponent

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Cassiopeia

VS

Mid

Yone

Cassiopeia vs Yone

Confidence mediumUpdated Jun 10, 2026

Overview

Control mid-range space to force Yone into extended fights where you stack poison and cast repeated (E).
Pressure Yone early to deny his (E)+(Q) combo setup and reduce his melee skirmisher threat.
Maintain medium lane pressure to prevent Yone from freely stacking (Q) and setting up knockups.

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison, then spam (E) for sustained damage while Yone is grounded.
Punish Yone if he uses (E) from a bad position by extending trades with repeated (E).
Save (W) to block or punish Yone's dashes and use (R) to stun if he faces you during all-ins.

Danger windows

(E) active window enables knockups and extended trades; avoid committing during this.
Respect Yone's third (Q) knockup and (R) displacement as hard engage threats.
Play cautiously when your (W) or (R) are down since Yone can engage or escape more safely then.

Early game

Use (Q) to apply poison early and punish Yone if he overextends without (E) available.
Hold (W) until Yone commits to a dash or engage to ground his mobility effectively.
Keep lane pressure moderate to disrupt Yone's ability to safely stack (Q) and prepare trades.

Power spikes

Level 6 unlocks (R), enabling strong all-in punishments when Yone faces you.
First mana/AP item boosts your sustained damage and mana pool for longer trades.
Respect Yone's level 3 when he unlocks (Q)-(W)-(E) combo and his first back power spike for attack speed.

Win conditions

Win extended fights by maintaining poison stacks and repeatedly casting (E) while controlling space with (W).
Punish Yone's cooldowns, especially his (E) misuse, with (Q) and (W) to deny engages and force resets.
Use (R) stun or slow when Yone faces you during all-ins to turn fights and secure lane dominance.