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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Cassiopeia vs Zilean MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Cassiopeia

VS

Mid

Zilean

Cassiopeia vs Zilean

Confidence mediumUpdated Jun 10, 2026

Overview

Use mid-range sustained trades to punish Zilean's low direct damage early.
Focus on landing (Q) to apply poison before committing to extended (E) damage.
Maintain spacing to avoid double bomb stuns and punish missed (W) or (R) windows.

Trading pattern

Start trades by landing (Q) to apply poison, then chain (E) for damage.
Use (W) to ground Zilean if he tries to close distance or escape.
Avoid trading when (Q) misses or (W) is down to prevent counter-engage.

Danger windows

Respect Zilean's double (Q) stun combo; avoid standing in bomb zones.
Be cautious when (W) is up, as it speeds Zilean or his ADC for quick trades.
Avoid committing when (R) is available, as it negates burst and forces target swaps.

Early game

Prioritize hitting level 6 first to access (R) for safer all-ins.
Thin the wave to reduce bomb zone setups and limit Zilean's poke.
Punish Zilean if he wastes (Q) or (W) cooldowns by stepping up for extended (E) trades.

Power spikes

Level 6 (R) unlocks strong all-in potential; track its cooldown to force or avoid fights.
First mana/AP item boosts sustained damage; increase pressure and extended trades afterward.
Post-level 3, punish Zilean's longer (W) cooldown and limited mobility with repeated (E) damage.

Win conditions

Convert lane priority into roams or objective control using (R) windows.
Force extended fights where repeated (E) outdamages Zilean's poke and utility.
Deny bomb setups by controlling wave and punishing cooldowns to limit Zilean's impact.

Tip: For Cassiopeia vs Zilean, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup