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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Cassiopeia vs Zoe MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Cassiopeia

VS

Mid

Zoe

Cassiopeia vs Zoe

Confidence mediumUpdated Jun 10, 2026

Overview

Use mid-range trades to apply poison and force Zoe into extended fights where (E) excels.
Deny Zoe safe angles for (E) by maintaining lane pressure and controlling space.
Exploit Zoe's reliance on landing (E) by punishing missed sleeps with sustained damage.

Trading pattern

Initiate trades by landing (Q) or (W) to apply poison, then chain (E) for sustained damage.
Punish Zoe immediately after she misses (E), as she becomes vulnerable to extended trades.
Hold (W) to block (R) repositioning angles or trap her during aggressive moves.

Danger windows

Avoid committing when (E) is up; her sleep sets up burst trades.
Be cautious if (W) is down, as Zoe can use mobility and poke more freely.
Maintain spacing when Zoe uses (R) to reposition for extended poke angles.

Early game

Prioritize landing (Q) to apply poison and open windows for repeated (E) trades.
Respect (E) cooldown; avoid extended trades while it is available.
Use (W) to ground Zoe's dashes and limit her mobility early.

Power spikes

At level 6, use (R) to punish Zoe if she faces you during all-ins.
After first mana/AP item, increase pressure with longer trades and sustained (E) damage.
Respect Zoe's level 6 (R) which extends her poke range and dodge potential.

Win conditions

Force Zoe into extended trades where repeated (E) outdamages her burst.
Use (W) to deny Zoe's dashes and control her movement during fights.
Capitalize on missed (E) or poor (R) timings to engage with (R) and secure kills.

Tip: For Cassiopeia vs Zoe, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 10, 2026New matchup