Dr. Mundo vs Vayne TOP Matchup Guide | LaneStomp

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Dr. Mundo

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Vayne

Dr. Mundo vs Vayne

Updated Jun 3, 2026

Overview

Focus on surviving early lane pressure by using (Q) to farm safely and avoid extended trades.
This is a scaling matchup where Mundo must outlast Vayne's poke and true damage by relying on health scaling and healing.

Trading pattern

Trade only when (Q) lands repeatedly to slow Vayne and limit her mobility.
Use your passive to block (E) crowd control and punish after it is down.
Avoid trading if (Q) misses or (R) is down, as Vayne can kite and outdamage you in short trades.

Danger windows

Be cautious when (E) is available, especially near walls where she can stun you.
Avoid extended trades before level 6 and before your first health item when you are easier to burst down.
Respect (R) stealth window combined with (Q) repositioning, which increases her all-in threat and kite potential.

Early game

Use (Q) to safely farm and avoid missing cleavers to prevent giving Vayne free poke windows.
Avoid engaging before level 6 and health items when you are more vulnerable to Vayne's true damage and (E) stun.
Respect Vayne's ability to kite and punish missed (Q) by keeping safe spacing and not overcommitting.

Power spikes

Level 6 (R) is a major spike; use it before lethal burst to sustain and chase down Vayne.
Health item spikes increase your durability and damage; pressure side lanes to force Vayne to spend time cutting through your health.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun; avoid fighting near walls and keep track of her cooldowns.

Win conditions

Survive early lane by consistent (Q) farming and passive use, then outscale Vayne through health and healing.
Use (R) to sustain through her burst and extend fights where your durability outlasts her damage.
Pressure side lanes with health item spikes to force Vayne into unfavorable duels and reduce her scaling impact.