This mid matchup is a medium lane pressure, medium scaling duel where Garen must manage short trades and passive health recovery to survive Cassiopeia's sustained poke.
Focus on denying Cassiopeia free farm by punishing her cooldowns and avoiding extended fights where her sustained damage outmatches you.
Trading pattern
Use (Q) to silence and start short trades, then follow with (E) spin damage, backing off before Cassiopeia can extend with repeated (E) and (W).
Punish Cassiopeia when her (Q) misses or (W) is on cooldown by stepping forward for quick trades that reset your passive.
Avoid trading when your passive health regen is low or (Q) is on cooldown, as you lack reach and can be kited easily.
Danger windows
(R) stun is a major danger; avoid facing her directly when it is available to prevent being locked down.
Her (W) grounding and slow can trap you in bad trades; do not commit when (W) is up and be ready to disengage.
You are vulnerable after using (Q) if you fail to close distance or if your passive is interrupted repeatedly by her poke.
Early game
Hold the wave near your side and punish Cassiopeia's CS attempts with short (Q) silence plus (E) trades.
Avoid extended trades before level 6 when your execute threat is low and Cassiopeia can outdamage you with repeated (E).
Respect her (W) slow and grounding by not committing to trades when it is available to block your (Q) engage or escape.
Power spikes
Level 6 is your major spike; use (R) execute to convert chip damage into kills and force Cassiopeia to play cautiously.
Your first bruiser or tank item spike increases your durability in trades, allowing repeated short engagements.
Respect Cassiopeia's level 6 (R) stun window by holding key defensive tools and avoid facing her directly during its cooldown.
Win conditions
Use short (Q)+(E) trades to chip Cassiopeia down and reach execute range for (R) kills.
Deny her free farm by punishing missed (Q) and (W) cooldowns and controlling wave position near your side.
After first item and level 6, repeat controlled trades to build health advantage and pressure her to play under threat of execute.
Tip: For Garen vs Cassiopeia, read overview, trading pattern, and danger windows first for a fast Mid lane check.