Heimerdinger vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Heimerdinger vs Vayne

Updated Jun 3, 2026

Overview

Use turret zones to control wave and deny Vayne safe farming space early and mid lane phases.
Prioritize lane pressure and anti-dive setup to prevent Vayne from scaling freely with her high mobility and true damage.
This is a control vs scaling matchup; maintain turret control to punish her fragile early game and delay her power spikes.

Trading pattern

Trade only when turrets are active and (E) is ready to lock Vayne down for turret and (W) damage.
Punish Vayne's use of (Q) forward by landing (E) and layering turret damage during her reposition cooldown.
Avoid fighting away from turrets or when (E) is down to minimize risk from her mobility and true damage.

Danger windows

Be cautious when turrets are cleared and (E) is on cooldown, as Vayne can engage or punish your low mobility.
Avoid overpushing without vision to prevent ganks exploiting your immobility.
Respect (E) wall stun potential and (R) stealth repositioning when fighting near terrain or in tight spaces.

Early game

Establish multiple turrets before level 3 to maximize zone control and punish Vayne's attempts to farm.
Hold (E) to stun Vayne when she tries to engage or (Q) aggressively into turret range.
Avoid pushing without vision to reduce vulnerability to ganks, as low mobility makes you an easy target.

Power spikes

At level 6, choose (R) upgrade to enhance burst or zone control based on fight needs; force Vayne to respect your upgraded abilities.
First AP item spike increases turret and spell damage; keep turrets alive to punish Vayne walking into your zone.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun; avoid extended fights without turret and (E) control.

Win conditions

Maintain turret zones to force Vayne to farm under pressure and punish her fragile early game.
Use (E) stun combined with turrets and upgraded abilities to deny her all-ins and secure objective setups.
Control wave and vision to avoid ganks, enabling you to safely build AP and leverage mid-game power spikes to dominate lane and objectives.