Kai'Sa vs Vayne ADC Matchup Guide | LaneStomp

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Kai'Sa

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ADC

Vayne

Kai'Sa vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

Kai'Sa wins by punishing Vayne's short-range CS attempts and isolated targets after support CC setup.
Vayne controls lane priority early with high mobility and poke, so Kai'Sa needs to farm safely toward item spikes.
The lane turns on Kai'Sa's ability to thin waves and commit all-ins only when plasma stacks and support setup align.

Trading pattern

Punish Vayne's last-hit animations by stepping forward only if enemy support cannot immediately trade back.
Avoid using (E) forward before (E) cooldown is spent to prevent getting stunned or engaged on.
Use (W) to apply plasma stacks when Vayne is isolated from minions and support CC is available to start all-in windows.

Danger windows

(E) can stun Kai'Sa against terrain; avoid using (E) aggressively near walls without support backup.
(R) stealth (Q) creates repositioning threats; respect this when stepping forward for CS or trades.
Enemy support controlling brush or threat zones negates Kai'Sa's last-hit punish windows; avoid trades then.

Early game

Use the first three waves to thin the minion wave, enabling (Q) to hit Vayne directly instead of minions.
Avoid stepping forward when (Q) is available to punish close CS attempts.
Track support brush control to decide if last-hit punishment on Vayne is safe or too risky.

Power spikes

First completed item unlocks evolved abilities, increasing burst and allowing safer all-ins with support setup.
Level 6 (R) enables repositioning onto plasma-marked Vayne targets, turning small CC into lethal engages.
Evolved (Q) damage is strongest when Vayne is separated from minions, so thin waves before committing trades.

Win conditions

Reach item and evolve thresholds to turn short windows into committed all-ins with support CC setup.
Convert health leads from last-hit punishments into wave crashes to take turret plates and dragon control.
Use (R) repositioning in teamfights to dive onto marked targets and maximize mixed damage output against Vayne's fragility.