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Overview

Role Plan

Danger Windows

Early Game

Power Spikes

Win Conditions

Lissandra vs Cassiopeia MID Matchup Guide | LaneStomp

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Champion

Opponent

RoleGenerate matchup

Lissandra

VS

Mid

Cassiopeia

Lissandra vs Cassiopeia

Updated May 31, 2026

Overview

Lissandra controls mid by punishing Cassiopeia's need to enter W and R range for trades.
Focus on denying Cassiopeia extended fights where she can stack E damage and poison.

Trading pattern

Trade when Cassiopeia's Cassiopeia W is down to reduce her ability to ground your mobility.
Use W to root Cassiopeia if she steps too close for Cassiopeia E trades.
Save R to lock down Cassiopeia when she is poisoned or overextends for reliable follow-up.

Danger windows

Avoid extended trades when Cassiopeia's Cassiopeia W is available to prevent being grounded.
Respect Cassiopeia R stun when facing her during all-ins.
Be cautious engaging without R available, as Cassiopeia can punish your cooldowns with sustained damage.

Early game

Use Q to farm safely and poke when Cassiopeia is vulnerable after missed Cassiopeia Q.
Hold W to root Cassiopeia when she tries to commit or dash into your zone.
Avoid using E aggressively without follow-up, as Cassiopeia can punish predictable engages.

Power spikes

Level 6 R is your key power spike to initiate or peel.
First AP or utility item completes your damage and survivability.
Respect Cassiopeia's level 6 Cassiopeia R and her first mana/AP item for her sustained damage.

Win conditions

Use W and R to lock down Cassiopeia and prevent her from stacking E damage.
Punish Cassiopeia's missed Cassiopeia Q and Cassiopeia W cooldowns with quick trades.
Coordinate with jungle to capitalize on your reliable lockdown for kills and roams.

Tip: For Lissandra vs Cassiopeia, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated May 31, 2026New matchup