Nasus vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Nasus vs Vayne

Updated Jun 3, 2026

Overview

Nasus must endure Vayne's early ranged pressure and focus on safe (Q) stacking to reach a strong mid-game power spike.
Avoid giving Vayne a passive lane to freely kite and scale; control wave near your side to limit her poke and all-in angles.
This is a scaling juggernaut vs ranged duelist matchup where Nasus aims to outscale and punish Vayne's limited waveclear and fragility.

Trading pattern

Trade only when (W) is up and Vayne is within melee range without (E) to disengage.
Use (E) to reduce her armor and prepare for stacked (Q) damage in extended trades.
Avoid fighting when (W) is down or Vayne can kite with (Q) stealth repositioning and (R) active.

Danger windows

Be cautious when (E) is up and she can (E) you into walls for stuns.
Nasus is vulnerable pre-6 and with low (Q) stacks; avoid extended trades and gank-prone wave states.
Avoid overextending without vision as Vayne's mobility and jungle pressure can punish hard dives or collapses.

Early game

Prioritize last-hitting with (Q) safely under tower or near your side to avoid Vayne's poke and (E) threat.
Use (W) to punish Vayne when she overextends or commits forward without (E) available.
Avoid early all-ins before (Q) stacks and level 6 when Vayne's mobility and (R) stealth make trades unfavorable.

Power spikes

Level 6 (R) grants Nasus durability for longer trades; use it to force fights only when (Q) stacks are meaningful.
High (Q) stack threshold turns Nasus into a dueling threat; pressure side lanes to force Vayne to respond.
Respect Vayne's level 6 (R) stealth and repositioning; avoid committing to all-ins without (W) or jungle support.

Win conditions

Survive early lane and stack (Q) safely near your tower to reach mid-game power spikes.
Use (W) slows and (R) durability to punish Vayne's overextensions and force side-lane duels.
Pressure side lanes once (Q) stacks and (R) are up to force Vayne into unfavorable isolated fights where you can outduel her.