Neeko vs Seraphine SUPPORT Matchup Guide | LaneStomp

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Champion

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Neeko

VS

Support

Seraphine

Neeko vs Seraphine

Confidence mediumUpdated Jun 9, 2026

Overview

Use brush control to threaten engage angles with (E) root and disguise for pick setups.
Prioritize denying Seraphine's ADC access by forcing her to use (W) shields inefficiently.
Leverage Neeko's burst and crowd control to pressure grouped fights and enable ADC follow-up.

Trading pattern

Fish for (E) through minions to root and burst before Seraphine can shield or heal.
Hold (R) for multi-target all-ins when (R) is down or enemies are clumped.
Deny brush to limit Seraphine's poke and disengage angles, enabling safer ADC follow-up.

Danger windows

Seraphine's empowered (E) root paired with ADC slows creates high engage threat; respect spacing.
(R) can charm multiple targets through minions; avoid clustering and hold peel cooldowns.
Losing brush control allows Seraphine to safely poke and set up teamfight ultimates; maintain vision.

Early game

Contest level 2 to disrupt Seraphine's empowered (E) root and slow combo.
Hold brush vision to prevent Seraphine from safely poking or setting up (R) angles.
Coordinate wave crash with ADC to create roam windows and deny Seraphine lane priority.

Power spikes

Level 2 unlocks Seraphine's poke and root, so contest wave and play around ADC follow-up.
Level 6 grants Neeko strong all-in with (R); use it to force Seraphine's ultimate or secure picks.
First AP item completion increases (E) and (Q) burst, enhancing lane pressure and poke potential.

Win conditions

Convert brush control and (E) roots into ADC access denial and forced enemy recalls.
Roam after wave crashes to pressure mid and secure river vision for dragon control.
Use (R) in grouped fights to create picks or force disengage, enabling favorable teamfight entry.