Orianna is a control mage with medium lane pressure who must manage ball placement to control the lane and create teamfight opportunities.
Vex has high early agency and lane pressure, so Orianna should avoid giving her free passive fear trades and focus on wave control to limit Vex's aggression.
Trading pattern
Trade by zoning with ball placement and poking with Q, then shield or speed with W and E to survive return damage.
Punish Vex when her passive fear is down or missed to avoid her electrocute proc.
Avoid reckless trades when Q is on cooldown to prevent being all-in'd by Vex's burst.
Danger windows
Avoid extended trades when Vex's passive fear is up, as it can force you out or set up electrocute.
Be cautious around Vex's R cooldown; without it she is less threatening and easier to pressure.
Orianna is vulnerable to direct all-ins before enough mana and AP; keep ball positioned defensively.
Early game
Use Q and W to poke safely while maintaining ball position to avoid Vex's passive fear trades.
Respect Vex's early threat by not overextending before level 6 when she gains R engage/reset.
Shield with E to mitigate burst when Vex uses her abilities aggressively.
Power spikes
Orianna's major spikes are level 6 R and first completed mage item.
Respect Vex's level 6 R engage and first AP burst item as strong all-in windows.
Orianna's scaling and teamfight control outvalue Vex's early burst if she survives early pressure.
Win conditions
Control the lane with precise ball placement to zone Vex and deny her passive fear trades.
Punish Vex when she fails to land fear or uses R aggressively and is on cooldown.
Reach level 6 and first item spike to leverage R shockwave for teamfights and lane dominance.
Tip: For Orianna vs Vex, read overview, trading pattern, and danger windows first for a fast Mid lane check.