Ryze should focus on safe scaling and controlled wave management to avoid giving Mordekaiser extended trades inside his passive range.
Prioritize stable farming and use waveclear to create opportunities for map plays with (R), denying Mordekaiser's preferred slow, isolated trades.
This is a scaling mage versus an AP juggernaut lane control matchup where Ryze must avoid early all-in pressure and aim for late-game sustained damage.
Trading pattern
Trade by applying (E) to spread marks and follow up with (Q) for empowered damage, holding (W) to root Mordekaiser if he commits.
Punish Mordekaiser when he misses (E) pull by stepping forward for quick (E)+(Q) trades.
Avoid trading when low on mana or when (W) shield is active, as you need multiple rotations to win trades.
Danger windows
Be cautious when (E) pull is available, as it sets up his isolated (Q) and passive damage.
Respect the level 6 (R) window where Mordekaiser can isolate you; save (W) root and positioning to avoid forced duels.
Avoid extended trades when (W) shield is charged, as he can convert it into healing during fights.
Early game
Play cautiously early, avoiding long trades before your first mana/AP item when your threat is low.
Use (E) and (Q) for short poke trades only when mana allows and Mordekaiser is not ready to pull with (E).
Keep the wave controlled to prevent Mordekaiser from forcing extended trades with his passive and (E) pull.
Power spikes
After your first mana/AP item, pressure the wave and trades more confidently while tracking Mordekaiser's cooldowns.
Respect Mordekaiser's level 6 (R) isolation; use your own (R) for map plays or defensive repositioning rather than forcing fights.
Mordekaiser's first AP bruiser item increases his sustain and durability; keep trades short and punish missed (E) pulls during this phase.
Win conditions
Scale safely through controlled farming and use (E)+(Q) rotations to chip Mordekaiser down when he overcommits.
Use waveclear to manage lane state and create opportunities for (R) to assist side lanes or escape isolation.
Punish Mordekaiser after missed (E) pulls and when his (W) shield is down to secure advantageous trades and deny his extended damage.
Tip: For Ryze vs Mordekaiser, read overview, trading pattern, and danger windows first for a fast Top lane check.