Samira vs Vayne ADC Matchup Guide | LaneStomp

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Samira

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ADC

Vayne

Samira vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on blocking (Q) and (E) with (W) to enable safe engage windows.
Samira wins short trades after support CC and punishes Vayne's close-range last-hit attempts.
Vayne scales better into extended fights; Samira must force quick resets and all-ins to snowball.

Trading pattern

Block (Q) or (E) with (W) before dashing in to stack Style.
Punish Vayne when she steps up for last hits if enemy support is out of zone or cooldowns.
Give up last-hit punish if enemy support controls brush or can immediately trade back.

Danger windows

Avoid trading when (E) is ready near terrain for a wall stun setup.
Respect enemy support presence controlling brush or engage zones that block your dash follow-up.
Be cautious when (R) is active, enabling stealth (Q) repositioning and extended dueling.

Early game

Use the first three waves to hold the wave near your side, limiting Vayne's dash angles.
Punish Vayne's last-hit attempts on low-health caster minions only if enemy support can't counter.
Avoid dashing early without support CC as (E) can stun into terrain and punish.

Power spikes

Level 6 (R) lets Samira follow support engage with high burst and reset potential; wait for CC.
First completed damage item strengthens Samira's all-in and reset threat; force fights with support setup.
Vayne's level 6 (R) stealth repositioning demands Samira to commit only after support CC disables escape.

Win conditions

Convert support engage into all-ins by stacking Style and resetting on low-health targets.
Use lane pressure to force Vayne under tower, denying safe CS and enabling plate and dragon control.
Snowball leads into item spikes and teamfight DPS windows by chaining resets after kills or assists.