Syndra vs Cassiopeia MID Matchup Guide | LaneStomp

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Syndra

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Mid

Cassiopeia

Syndra vs Cassiopeia

Updated May 31, 2026

Overview

Syndra is a burst control mage who must use Q and W to zone and poke while holding E for punishing Cassiopeia's commits.
Pressure Cassiopeia early to deny her safe scaling and avoid giving her room for extended E trades.

Trading pattern

Poke with Q and W to control space, then punish Cassiopeia's movement into W or Q range with E stun into R burst.
Respect Cassiopeia's W cooldown as it grounds dashes; trade more aggressively when W is down.
Avoid extended trades where Cassiopeia can stack E damage; focus on quick burst combos instead.

Danger windows

Be cautious when E is on cooldown as Syndra has no mobility or escape.
Respect Cassiopeia's level 6 R stun window; avoid facing her directly during all-ins.
Punish Cassiopeia if she misses Q or W, as her immediate trade threat drops significantly.

Early game

Use Q and W to poke and keep Cassiopeia from applying poison safely.
Avoid committing if E is down since Syndra is immobile and vulnerable to Cassiopeia's follow-up.
Contest Cassiopeia's attempts to land Q and apply poison by spacing aggressively with spheres.

Power spikes

Syndra's major spikes are level 6 R for burst and first completed mage item for damage.
Cassiopeia's major spikes are level 6 R and first mana/AP item that enable sustained trades.
Syndra's level 11 and 16 Q upgrades improve poke frequency and stun threat, strengthening lane control.

Win conditions

Use Q and W to zone Cassiopeia and prevent her from safely applying poison and extending trades.
Look for E stuns into R burst when Cassiopeia is out of position or W is down.
Deny Cassiopeia scaling by pressuring early and forcing short trades where Syndra's burst excels.