Tristana vs Vayne ADC Matchup Guide | LaneStomp

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Champion

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Tristana

VS

ADC

Vayne

Tristana vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Tristana's level 2 all-in with support follow-up against Vayne's short-range trades.
Tristana benefits from pushing to force Vayne into risky last-hit positions where (E) burst and (W) jump punish.
Vayne scales well but struggles under turret pressure and wave crashes where Tristana can stack (E).

Trading pattern

Step forward to auto-attack Vayne during her last-hit animations only if enemy support cannot zone or engage.
Use (E) to stack burst damage before committing to (W) jump all-in when support cooldowns allow follow-up.
Drop punish windows if enemy support controls brush or threat zone to avoid losing HP for one auto.

Danger windows

Avoid engaging when (E) is available, especially near walls where she can stun and punish your jump.
Respect enemy support presence in brush or river that can immediately follow your (W) jump with CC or poke.
Be cautious when your passive wave push exposes you to ganks or forced trades without (W) reset available.

Early game

Push first two waves to hit level 2 before Vayne and threaten (W) all-in with support ready.
Punish Vayne's last-hit attempts on caster minions when her (Q) is down and support can't trade back.
Avoid jumping into large minion waves to prevent minion damage and enemy support peel from turning trades against you.

Power spikes

Level 2 unlocks (W) jump and (E) burst, enabling sudden all-ins; push wave early to reach this first.
First completed marksman item boosts (E) turret pressure and all-in burst, letting you convert kills into plates.
Late-game range and reset potential allow safe extended trades and teamfight DPS dominance over Vayne.

Win conditions

Convert winning trades into turret plates by crashing waves and fully stacking (E) before recalls.
Use level and item spikes to force Vayne off the wave, deny her farm, and secure dragon vision control.
Snowball resets from (W) jump kills to pressure mid-game objectives and teamfight positioning for DPS access.