Varus vs Vayne ADC Matchup Guide | LaneStomp

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Varus

VS

ADC

Vayne

Varus vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

Varus wins short trades by landing poke and blight stacks before Vayne can reposition with (Q).
Vayne excels in extended trades and dueling after level 6 with stealth and true damage.
Use wave control to create poke angles and punish Vayne's last-hit attempts when she oversteps.

Trading pattern

Punish Vayne when she steps up for caster minion last hits with charged (Q) plus autos if support can't punish.
Use (E) slow to lock Vayne during her last-hit animations and detonate blight stacks for burst trades.
Avoid charging (Q) when (Q) is available to dodge or when enemy support threatens immediate countertrade.

Danger windows

(E) wall stun combined with (R) stealth and (Q) reposition creates lethal all-in windows.
Avoid charging (Q) in range of enemy engage or when (R) is down, as you lack mobility to escape.
Respect enemy support positioning that can follow up instantly after (E) or (Q) engages.

Early game

Use the first three waves to thin the wave and position for charged (Q) poke on Vayne's last hits.
Avoid charging (Q) near enemy engage range or when support is too far back.
Hold (R) for level 6 to counter Vayne's all-in or to peel against her engage.

Power spikes

Level 6 (R) enables pick threat and self-peel; hold it to punish immobile Vayne or stop her engage.
First completed damage item increases poke pressure, allowing safer wave crashes and dragon control.
Use item spike to pressure Vayne before she reaches two-item duel strength.

Win conditions

Convert poke damage and blight stacks into health leads forcing Vayne off the wave for plates and dragon.
Use (R) pick threat to secure bot priority and vision control around dragon before fights.
Scale into teamfights where your poke and pick setup outvalue Vayne's dueling and stealth repositioning.