Vayne vs Anivia ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Anivia

Vayne vs Anivia

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on punishing Anivia's low mobility when she walks up for caster minions.
Vayne wins extended trades through (W) true damage and (E) terrain stuns, while Anivia controls wave with (R) zoning.
Hold wave near your side to deny Anivia safe farm and force her into risky last-hit positions.

Trading pattern

Punish Anivia's missed (Q) by stepping forward during her last-hit animations if support threat is low.
Hold (E) to (E) Anivia into bot lane wall for reliable stuns and burst trades.
Use (Q) stealth reposition after trades to avoid (Q) stun follow-ups and reset spacing safely.

Danger windows

Respect (Q) stun combo, especially if enemy support is ready to follow up.
Avoid trading or stepping forward when (R) is active, as her slow and damage zone punishes close range.
Be cautious if enemy support controls brush or river, as it blocks your punish windows on Anivia's last hits.

Early game

Use (Q) to reposition and auto Anivia when she last-hits low-health caster minions if enemy support can't punish.
Avoid pushing early waves without vision to prevent ganks and losing control to Anivia's waveclear.
Track (Q) cooldown to step up for trades when it's down, reducing her poke threat.

Power spikes

Level 6 (R) grants stealth on (Q), enabling safer all-ins and outplays against Anivia's low mobility.
First marksman item spike improves (W) true damage trades, letting you threaten kills if Anivia mispositions.
Two-item spike turns Vayne into a side-lane duelist that punishes Anivia's immobility and forces her to group.

Win conditions

Convert punished last hits into health leads and crash waves to take turret plates early.
Use side-lane pressure after two items to force Anivia to group or lose farm under tower.
Leverage (R) stealth repositioning in teamfights to safely output DPS while avoiding Anivia's zoning (R).