Vayne vs Garen TOP Matchup Guide | LaneStomp

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Garen

Vayne vs Garen

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to keep Garen at bay and deny his short trades.
Focus on scaling through safe farming and punishing Garen's predictable engage pattern with (E) terrain stuns.

Trading pattern

Trade only when (E) is available to punish Garen's engage and avoid fighting near walls unless you control spacing.
Avoid using (Q) forward into (Q) silence, as it enables his all-in.
Use (Q) to reposition and kite after (E) ends, extending trades where you have the advantage.

Danger windows

Be cautious when Garen has (Q) ready, as his silence enables a dangerous engage.
Avoid pushing without vision to prevent ganks that exploit your low waveclear and fragility.
Respect Garen's execute range post-level 6, especially if you are low on health after trades.

Early game

Keep the wave on your side to avoid pushing without vision and becoming vulnerable to ganks.
Use autos and (Q) to poke Garen while maintaining distance, avoiding extended trades before level 6.
Hold (E) to punish (Q) engage or to stun him against walls if he overcommits.

Power spikes

At level 6, activate (R) to gain stealth on (Q) and outplay Garen's all-in attempts.
After acquiring two core items, pressure side lanes aggressively to leverage your true damage and kite Garen's durability.
Respect Garen's level 6 (R) execute threat by avoiding low health states and disengaging when he has cooldowns up.

Win conditions

Use your superior range and (Q) mobility to deny Garen safe trades and scale into a strong side-lane duelist.
Punish Garen's predictable engage by stunning him into terrain with (E) and kiting with (Q).
Reach your two-item power spike to pressure side lanes and outduel Garen in extended fights while maintaining vision control.