Vayne vs Gwen TOP Matchup Guide | LaneStomp

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Gwen

Vayne vs Gwen

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to pressure Gwen and deny her safe stacking of (Q).
Prioritize lane pressure and avoid giving Gwen extended trades inside her (W) mist zone where she scales better.
This is a scaling duel matchup where Vayne wants to out-range and kite Gwen before hitting two-item true damage spikes.

Trading pattern

Trade primarily by auto-attacking from max range, using (Q) to reposition and avoid (E) dash engage.
Hold (E) to (E) Gwen into walls for stuns, especially after she wastes (W) or commits to extended trades.
Punish Gwen when her (W) is down by stepping forward for short trades before she can block your retaliation.

Danger windows

Gwen is most dangerous when (Q) is fully stacked and (W) is active, forcing you to respect her extended damage and untargetability.
Avoid fighting near walls without (E) ready, as Gwen can capitalize on close range with her (R) slow and (Q) center damage.
Be cautious pushing without vision, as Gwen's mid-game scaling and jungle pressure can punish overextensions.

Early game

Keep the wave on your side early to avoid being forced into Gwen's extended trades when her (Q) stacks matter most.
Use (E) to punish Gwen when she mispositions near walls, but avoid pushing without vision to reduce gank risk.
Avoid using (Q) forward when Gwen's engage is ready to prevent getting caught inside her mist zone.

Power spikes

At level 6, use (R) to gain stealth repositioning and outplay Gwen's extended all-ins; avoid fighting inside her (W) mist zone.
After your two-item spike, pressure side lanes aggressively with vision and kite space to exploit Gwen's lower mobility.
Respect Gwen's level 6 (R) slow and chase; disengage before she can recast needles and force extended fights inside her (W).

Win conditions

Deny Gwen safe stacking of (Q) by controlling wave and using ranged poke to force short trades.
Use (E) to (E) Gwen into walls and (R) stealth to outplay her all-ins and scale safely.
Reach two-item true damage spikes to dominate side-lane duels and kite Gwen's lower mobility in extended fights.