Vayne vs Kai'Sa ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Kai'Sa

Vayne vs Kai'Sa

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Vayne punishing Kai'Sa's short-range CS attempts with (Q) autos and (E) terrain stuns.
Vayne wins extended trades through true damage and stealth repositioning, while Kai'Sa relies on isolated burst windows.
Keep wave near your side to deny Kai'Sa safe access to evolve and item spikes for all-in threat.

Trading pattern

Step forward to auto Kai'Sa during last-hit animations when her support is out of zone or engage range.
Hold (E) to (E) Kai'Sa into bot lane walls for stuns, especially after she uses (E) forward.
Use (Q) to reposition and dodge (W) poke, then retaliate with autos when she is isolated from minions.

Danger windows

Kai'Sa's all-in is strongest when her support initiates CC and she follows with (R) reposition.
Avoid stepping up when (E) is available for engage or when her support controls brush or river.
Respect (W) mark application timing as it enables her burst and follow-up potential.

Early game

Use the first three waves to hold the wave near your tower, limiting Kai'Sa's dash and poke angles.
Punish Kai'Sa's last-hit attempts on caster minions only if enemy support cannot immediately trade back.
Avoid pushing without vision to prevent Kai'Sa exploiting her mobility and support setup for all-ins.

Power spikes

Level 6 (R) grants stealth (Q) repositioning, letting Vayne outplay Kai'Sa's all-in attempts.
Two-item spike turns Vayne into a true damage threat that punishes Kai'Sa's melee range and isolated targets.
First marksman item improves Vayne's poke and wave control, increasing pressure before Kai'Sa evolves.

Win conditions

Convert last-hit punishments into health leads to force Kai'Sa off the wave and deny evolve progress.
Crash waves near your tower to take turret plates and set up dragon control with your team.
Scale into side-lane duels using (R) stealth and (W) true damage to out-damage Kai'Sa in extended fights.