Vayne vs Miss Fortune ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Miss Fortune

Vayne vs Miss Fortune

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on Vayne punishing Miss Fortune's short-range CS attempts with (Q) autos and spacing.
Vayne wins extended trades and scales better, but must avoid Miss Fortune's poke through low-health minions.
Control wave near your side to deny safe (Q) bounce angles and reduce Miss Fortune's poke pressure.

Trading pattern

Hit Miss Fortune during her last-hit animations when she stands near low-health minions and support can't trade back.
Hold (E) to (E) her into bot lane walls for stuns rather than using it for poke.
Avoid using (Q) forward when her (E) slow is up or enemy support controls brush to prevent engage risk.

Danger windows

Respect (Q) bounce poke when standing behind low-health minions; avoid stepping up then.
Avoid trading or stepping forward when Miss Fortune's support can immediately follow or zone from brush.
Beware of (R) channel if enemy support has CC or terrain control to lock you down.

Early game

Use the first three waves to keep the wave on your side, denying Miss Fortune clean (Q) bounce angles.
Punish her when she steps up for caster minion last hits if enemy support can't contest.
Avoid pushing without vision to prevent ganks and losing (E) wall stun angles.

Power spikes

Level 6 (R) lets Vayne stealth reposition with (Q), outplaying Miss Fortune's poke and all-ins.
First marksman item spike increases Vayne's dueling and CS punish potential, pressuring Miss Fortune's lane safety.
Two-item side-lane spike turns Vayne into a strong anti-tank DPS, enabling safe side-lane pressure away from Miss Fortune.

Win conditions

Convert last-hit punish windows into health leads to force Miss Fortune recalls and secure plates.
Use lane priority and vision to set up dragon fights where you can kite and avoid (R) channels.
Scale into side-lane duels and teamfights where your true damage and stealth repositioning outmatch Miss Fortune's burst.