Vayne vs Mordekaiser TOP Matchup Guide | LaneStomp

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Mordekaiser

Vayne vs Mordekaiser

Updated Jun 4, 2026

Overview

Use ranged spacing and high mobility to pressure Mordekaiser and deny him easy extended trades.
Prioritize kiting and punishing his lack of mobility to maintain lane control and scale safely.

Trading pattern

Trade by auto-attacking from max range and using (Q) to reposition safely.
Hold (E) to (E) Mordekaiser into walls for stuns rather than using it aggressively.
Punish missed (E) pulls by stepping forward to trade while his engage threat is down.

Danger windows

Be cautious when Mordekaiser lands (E) pull combined with (Q) and passive damage; avoid extended trades in this window.
Respect his (R) isolation, especially if he has health or item advantage, as it forces a dangerous 1v1.
Avoid fighting near walls without control of spacing, as (E) can stun you and lead to lethal trades.

Early game

Keep the wave on your side to avoid getting pulled by (E) and punished in melee range.
Use (Q) to reposition and avoid his (E) pull attempts early.
Avoid pushing without vision to reduce gank risk and prevent forced all-ins.

Power spikes

At level 6, use (R) stealth and empowered dueling to outplay his all-in attempts.
After your two-item spike, pressure side lanes with vision and kite space to exploit your true damage.
Respect Mordekaiser's level 6 (R) isolation by saving mobility and defensive cooldowns for the realm window.

Win conditions

Use ranged spacing, (Q) repositioning, and (E) wall stuns to deny Mordekaiser easy engages and scale safely.
Exploit his low mobility by punishing missed (E) and forcing short trades.
Reach your two-item power spike to pressure side lanes and outduel him with true damage and stealth repositioning.