Vayne vs Nasus TOP Matchup Guide | LaneStomp

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Nasus

Vayne vs Nasus

Updated Jun 4, 2026

Overview

Use ranged spacing and high mobility to pressure Nasus and deny his safe stacking early game.
Prioritize lane pressure and avoid giving Nasus a passive farming lane to delay his scaling juggernaut power.

Trading pattern

Trade by auto-attacking from max range, using (Q) to reposition and avoid (W) slow.
Hold (E) to (E) Nasus into walls only when he commits to engage, punishing his low mobility.
Avoid extended trades when (E) is down or when Nasus has (R) active to reduce his durability advantage.

Danger windows

Nasus is dangerous when (W) slow is available and (R) is active, enabling extended trades.
Be cautious when Nasus has high (Q) stacks and can punish close-range engagements.
Vulnerable to ganks if you push without vision due to low waveclear and fragility.

Early game

Abuse your mobility and ranged attacks to poke and harass Nasus before he stacks (Q).
Keep the wave controlled near your side to reduce Nasus's safe farming and limit his (W) slow effectiveness.
Avoid pushing without vision to prevent ganks and punish Nasus's low early pressure.

Power spikes

Level 6 (R) empowers your dueling and stealth repositioning; use (R) when you have space to kite.
Two-item spike increases your true damage DPS; pressure side lanes and force Nasus into unfavorable fights.
Respect Nasus's level 6 (R) and high (Q) stacks; avoid prolonged fights where he can use (W) slow and repeated (Q) damage.

Win conditions

Deny Nasus early farm by pressuring with ranged autos and kiting around (E) cooldowns.
Use your mobility and (R) stealth to outplay Nasus's engages and avoid his (W) slow.
Scale into side-lane duels post two-item spike where your true damage and kiting outmatch Nasus's durability.