Vayne vs Pantheon TOP Matchup Guide | LaneStomp

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Pantheon

Vayne vs Pantheon

Updated Jun 4, 2026

Overview

Prioritize ranged spacing and avoid Pantheon's point-and-click (W) stun to maintain lane control.
This is a scale-oriented matchup where Vayne must deny Pantheon early empowered trades and survive to reach late-game true damage dueling.

Trading pattern

Trade from max range with autos, using (Q) to maintain spacing and reposition safely.
Punish Pantheon immediately after he uses (W) as his engage becomes predictable and his damage block (E) may be down.
Avoid using (Q) forward into Pantheon's engage window to prevent being caught by his stun or burst.

Danger windows

Be cautious when (W) stun is available and his passive is stacked for empowered trades.
Avoid extended trades when (E) damage block is up, as it reduces your damage return.
Watch for ganks if you push without vision, as Pantheon's early pressure and stun make you vulnerable.

Early game

Use (Q) to reposition and poke while avoiding (W) stun range.
Hold (E) to punish Pantheon when he commits to engage or tries to approach near walls.
Avoid pushing the wave without vision to reduce gank risk and prevent Pantheon from punishing with empowered trades.

Power spikes

At level 6, activate (R) to gain stealth repositioning and outplay Pantheon's engage attempts.
After acquiring two core items, pressure Pantheon in side-lane duels using true damage and kite space.
Respect Pantheon's level 2-3 empowered trades and (W) stun by playing cautiously and holding (E) for counter-engage.

Win conditions

Use ranged spacing and (Q) stealth repositioning to deny Pantheon early lane control and avoid his stun.
Exploit Pantheon's predictable engage by holding (E) to (E) him into walls for stuns and counter trades.
Scale into side-lane duels with two items and (R) active to pressure Pantheon and carry through true damage DPS.