Vayne vs Ryze TOP Matchup Guide | LaneStomp

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Ryze

Vayne vs Ryze

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to deny Ryze's short-range poke and avoid his root engage.
Prioritize lane pressure to prevent Ryze from farming safely and scaling into his spell rotations.
This is a scaling duel focused matchup where Vayne must pressure early and avoid giving Ryze free scaling windows.

Trading pattern

Trade primarily with autos from max range, using (Q) to maintain spacing and hold (E) to punish Ryze's engage or pin him against terrain.
Punish Ryze when he steps forward to cast (E) and (W) by using (E) to (E) him into walls.
Avoid committing to trades when (E) is down or Ryze has mana for multiple spell rotations.

Danger windows

Be cautious when Ryze has full mana and cooldowns to cycle (E), (Q), and (W) for root setups.
Avoid fighting near walls without (E) ready, as Ryze's root can lock you down for follow-up damage.
Watch for (R) availability enabling roams or coordinated plays that can leave you isolated.

Early game

Keep the wave controlled near your side to avoid overextending and being vulnerable to (W) root and jungle ganks.
Use (Q) to reposition and poke Ryze safely without stepping into his (E) and (W) range.
Avoid pushing the wave without vision to reduce risk from Ryze's follow-up trades or roams.

Power spikes

At level 6, activate (R) to gain stealth repositioning and outplay Ryze's root and spell combos.
After your first two core items, pressure side lanes aggressively as your true damage outscales Ryze's sustained mage damage.
Respect Ryze's first mana/AP item spike by playing cautiously and avoiding extended trades when he gains better spell rotations.

Win conditions

Use ranged poke and (Q) stealth repositioning to deny Ryze safe farming and prevent his scaling.
Exploit Ryze's short range by punishing his attempts to engage with (E) into terrain stuns.
Reach your two-item power spike to dominate side-lane duels and apply pressure while maintaining vision and kite space.