Vayne vs Sett TOP Matchup Guide | LaneStomp

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Sett

Vayne vs Sett

Updated Jun 4, 2026

Overview

Use ranged spacing and (Q) repositioning to deny Sett melee trades and avoid his (E) pull and (W) true damage burst.
Maintain lane pressure by controlling wave position to prevent Sett from safely engaging and building grit.

Trading pattern

Trade by auto-attacking from max range and using (Q) to maintain spacing, holding (E) to (E) Sett into walls for stuns.
Punish Sett after he uses (E) or misses (W) by stepping forward to deal damage safely.
Avoid engaging when (E) is down or (W) shield is up to reduce risk of burst damage.

Danger windows

Sett is most dangerous when he has grit built and can land centered (W) true damage; avoid close melee range during these windows.
Respect (E) pull and stun, especially near minions or walls that enable his combo.
Be cautious after using (E) as your engage is down and Sett can capitalize with his (W) shield and (R) displacement.

Early game

Focus on keeping the wave on your side to avoid being forced into (E) and (W) range.
Use (Q) to reposition and punish Sett when he misses (E) or wastes (W) by sidestepping its center.
Avoid pushing without vision to reduce vulnerability to Sett's all-in and jungle ganks.

Power spikes

Level 6 (R) empowers your dueling and stealth repositioning; use it when you have space to kite and punish Sett's engage.
Two-item spike increases your true damage DPS; pressure side lanes and kite bruisers like Sett who struggle against your damage.
Respect Sett's level 6 (R) slam which can reposition you into danger; keep spacing to avoid forced brawls.

Win conditions

Deny Sett melee trades by using ranged autos and (Q) to reposition, then punish his cooldowns with (E) wall stuns.
Scale into your two-item power spike to dominate side-lane duels where you can kite and shred Sett.
Use (R) stealth tumbles to outplay Sett's all-ins and maintain safe spacing in extended fights.