Vayne vs Twitch ADC Matchup Guide | LaneStomp

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Vayne

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ADC

Twitch

Vayne vs Twitch

Confidence mediumUpdated Jun 7, 2026

Overview

The lane turns on Vayne punishing Twitch's close-range CS attempts with (Q) autos and (E) terrain stuns.
Vayne wins extended trades by kiting and stacking true damage while Twitch relies on stealth and grouped poke.
Maintain wave near your side to deny Twitch safe stealth re-entries and force him under tower.

Trading pattern

Step forward to auto Twitch when he commits to last hitting caster minions and enemy support cannot zone.
Use (Q) to reposition after autos and maintain distance, holding (E) to (E) Twitch into lane walls for stuns.
Avoid using (Q) forward when Twitch's stealth is available to prevent easy engage or burst trades.

Danger windows

Twitch is most dangerous when (Q) stealth is up with support ready to engage from fog or brush.
Avoid stepping up near low-health minions when (W) slow and (E) poison stacks are active.
Do not punish last hits if enemy support controls brush or can immediately trade back after your step forward.

Early game

Use the first three waves to hold the wave near your tower and punish Twitch stepping up for caster minions.
At level 2, punish Twitch's lack of dash by autoing during his last-hit animations if enemy support is not threatening.
Avoid pushing without vision to prevent Twitch's stealth ambushes and support follow-ups.

Power spikes

Level 6 (R) empowers Vayne's dueling with stealth repositioning, letting you outplay Twitch's engage attempts.
First marksman item spike allows safer last-hit punishment and better wave control versus Twitch's poke.
Two-item side-lane spike significantly increases true damage DPS, enabling you to pressure Twitch in isolated duels.

Win conditions

Convert lane pressure by denying Twitch CS and forcing him under tower before first item spikes.
Use recalls and wave crashes to secure plates and dragon setup, leveraging superior dueling after (R) and item spikes.
Scale into side-lane duels and teamfights where Vayne's mobility and true damage outmatch Twitch's stealth poke.