Vladimir vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Vladimir vs Vayne

Updated Jun 4, 2026

Overview

Vladimir must manage a low-pressure early lane focusing on surviving and farming safely against Vayne's high early agency and poke.
Prioritize scaling by avoiding early forced fights and using (Q) sustain to weather Vayne's ranged harassment.
This is a scale-vs-scale matchup where Vladimir aims for teamfight impact while respecting Vayne's early lane dominance.

Trading pattern

Trade around empowered (Q) windows, using (Q) to sustain through poke and only engage when (W) is available to negate Vayne's damage or (E) engage.
Punish Vayne if she misuses (E) or (Q) aggressively by stepping forward for short trades.
Avoid trading when (W) is down or empowered (Q) is not ready, as Vayne's range and true damage can punish you.

Danger windows

Vayne is most dangerous when (R) is active, granting stealth on (Q) and enabling outplays; avoid extended trades during this window.
Be cautious when (W) is down, as you lose your main defensive tool against Vayne's true damage and (E) engage.
Watch for (E) wall stun attempts near terrain and avoid fighting close to walls without (W) ready.

Early game

Avoid pushing the wave early to prevent Vayne from punishing with ranged autos and (Q) repositioning.
Use empowered (Q) for short trades only when safe, and save (W) to deny Vayne's all-in attempts or (E) wall stuns.
Focus on farming under pressure and avoid extended trades before level 6 and first item spike.

Power spikes

Level 6 (R) is a major spike; use it to threaten all-ins or teamfights and force Vayne to respect your burst.
First completed AP item increases your trading power; pressure waves and trades more confidently while tracking Vayne's cooldowns.
Respect Vayne's level 6 (R) stealth repositioning and (E) wall stun to avoid lethal trades.

Win conditions

Survive early lane by using (Q) sustain and (W) defensively, then scale into mid-game with your (R) burst in grouped fights.
Exploit Vayne's long (W) cooldown by forcing trades or wave pressure immediately after you use it.
Use empowered (Q) trades and item spikes to safely farm and reach your late-game teamfight damage potential.