Warwick vs Vayne TOP Matchup Guide | LaneStomp

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Vayne

Warwick vs Vayne

Updated Jun 4, 2026

Overview

Warwick should leverage his early dueling strength to pressure Vayne and deny her safe scaling opportunities.
Prioritize extended melee fights where Warwick's sustain and fear can outlast Vayne's ranged harassment.
This matchup is a snowball vs scale scenario; Warwick must snowball early to prevent Vayne from reaching her late-game power.

Trading pattern

Engage in extended melee trades to maximize (Q) healing and hold (E) to fear Vayne's burst attempts.
Use (R) to suppress Vayne after baiting her (E) or when she is low health to prevent her escape.
Punish Vayne's missed (E) by committing to all-ins before she can reposition or kite.

Danger windows

Be cautious when (E) is down, as Vayne's burst and (E) wall stun become more threatening.
Avoid committing to all-ins when (R) is on cooldown to prevent losing pick potential.
Watch for ganks if you push wave without vision, as Warwick's limited waveclear can expose you.

Early game

Use levels 1-3 to force trades where (E) absorbs Vayne's burst and (Q) sustains Warwick through damage.
Avoid letting Vayne kite freely by controlling wave position and limiting her space to use (Q) safely.
Prepare to punish Vayne's forward (Q) usage or (E) cooldown windows with immediate all-ins.

Power spikes

At level 3, Warwick gains full kit enabling strong sustain trades; use (E) to absorb damage and (Q) to chase.
At level 6, (R) unlocks powerful suppression; use it to force picks or all-ins when Vayne can't dodge.
Respect Vayne's level 6 (R) stealth repositioning and (Q) stealth to avoid getting kited or outplayed.

Win conditions

Win by forcing extended melee fights where Warwick's sustain and fear dominate Vayne's ranged poke.
Use (W) to track and chase low-health Vayne, punishing her retreat attempts.
Secure kills with (R) suppression after baiting her cooldowns, snowballing to deny her scaling and control the lane.