Zed vs Lissandra MID Matchup Guide | LaneStomp

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Zed

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Mid

Lissandra

Zed vs Lissandra

Updated Jun 1, 2026

Overview

Zed is a high-mobility assassin looking to pressure and punish Lissandra before she can safely engage with her crowd control.
Prioritize lane pressure to deny Lissandra a calm, controlled wave and prevent her from setting up ganks or roams.

Trading pattern

Use W + E for guaranteed damage, then Q to poke or finish, saving R for all-in or to dodge Lissandra W root.
Respect Lissandra W root and R stun; avoid engaging when these are available or when Lissandra has jungle follow-up.
Punish Lissandra if she uses E forward without follow-up by engaging quickly before she can escape.

Danger windows

Lissandra is most dangerous when R is up to lock you down or self-stasis to negate your burst.
Avoid committing when Lissandra's W root and E engage are off cooldown and jungle is nearby.
Be cautious if you miss W engage, as you become vulnerable to her counter-engage and crowd control.

Early game

Avoid extended fights before level 3 as Zed is vulnerable and Lissandra can punish early commits with W root.
Use early wave control to keep Lissandra from comfortably farming and force her to use defensive cooldowns.
Look for short trades after level 3 when W-E-Q combo is available to harass and chip her down.

Power spikes

Zed's major spikes: level 3 for full W-E-Q combo, level 6 for R all-in, and first lethality item.
Respect Lissandra's level 6 R for lockdown and self-peel; avoid all-ins when R is available.
Lissandra's first completed AP or utility item increases her threat; play around this timing.

Win conditions

Use high mobility and burst to punish Lissandra's cooldowns and force her to play defensively.
Deny her the chance to safely use E engage by punishing its cast and positioning aggressively.
Reach level 6 and item spikes to all-in decisively, focusing on bursting her before she can lock you down.