Zeri vs Vayne ADC Matchup Guide | LaneStomp

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Champion

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Zeri

VS

ADC

Vayne

Zeri vs Vayne

Confidence mediumUpdated Jun 7, 2026

Overview

This lane turns on punishing Vayne's short-range CS attempts with (W) through walls.
Zeri wins extended fights by kiting with (R) and using wall (E) for safety and chase.
Vayne pressures early with (Q) reposition and (E) wall stun, so avoid forced short trades before items.

Trading pattern

Punish Vayne's last-hit animations when enemy support cannot immediately trade back.
Use (W) through walls to hit Vayne on predictable CS paths, forcing her back.
Avoid stepping forward when (E) is available or Vayne's support controls brush or engage zones.

Danger windows

(E) wall stun combined with support follow-up creates lethal all-in windows; respect this when (E) is up.
Avoid trading when (R) is active and she can stealth reposition with (Q).
Stepping into brush or river control without vision exposes you to Vayne's engage and support ganks.

Early game

Hold the wave near your side to limit (Q) dash angles and punish last hits.
Use (W) through walls to poke Vayne when she walks up for caster minions.
Avoid pushing without vision to prevent (E) engage and support follow-up.

Power spikes

Level 6 (R) lets Zeri kite extended fights, turning skirmishes in your favor; use it to chase or disengage.
First completed marksman item strengthens your poke and wave control, enabling safer CS punishment.
Two-item spike enhances your sustained DPS and kiting, making it risky for Vayne to all-in near walls.

Win conditions

Convert health leads into wave crashes to take turret plates and force Vayne recalls.
Use wall (W) poke and (E) mobility to secure safe recalls and reach item spikes.
Kite extended fights with (R) active around terrain to maximize DPS and avoid Vayne's all-in attempts.