Zilean vs Annie MID Matchup Guide

Champion

Opponent

Start here

Read Overview → Trading Pattern → Danger Windows first for the fastest Mid lane plan.

Zilean into Anniemedium

Overview

Control lane by zoning Annie with double bombs and speed manipulation to limit her burst trades.
Force Annie to use for waveclear to drain her mana and open all-in windows.
Use to negate Annie's burst and protect your ADC or yourself.

Respect Annie's full passive stun stack and combo for lethal all-ins.
Avoid overextending when is on cooldown and Annie's engage is ready.
Beware of Annie's burst power spike after her first completed AP item; play around this timing.

Hit level 2 first to threaten double bomb plus speed trades and force Annie back.
Push wave early to force Annie to overextend and punish her limited mana pool.
Avoid standing near Annie's passive stun stacks to prevent sudden all-ins.

Level 2 unlocks double bomb plus speed, increasing poke and disengage potential.
Level 3 grants for double bomb resets, enhancing trade threat.
Level 6 forces Annie to hesitate on committing burst or all-in attempts.

Land double bombs to zone Annie and create windows for your ADC to trade safely.
Use speed to enable your ADC's kite or engage during skirmishes.
Save to deny Annie's burst and turn fights in your favor mid to late game.

Tactical tip

For Zilean vs Annie, read overview, trading pattern, and danger windows first for a fast Mid lane check.

Updated Jun 27, 2026New matchup